GTX13648
MBD1 antibody
Cannot supply to this region.
- SKU:
- GTX13648
- Additional Names:
- methyl-CpG binding domain protein 1 , CXXC3 , PCM1 , RFT
- Application:
- WB
- Concentration:
- 0.5 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- This antibody was developed by immunizing rabbits with a mixture of synthetic peptides corresponding to amino acids 98-113 (RQVGPQSGEVRKEAPR) and 391-405 (SESEDGAGSPPPYRR) of human MBD1.
- Uniprot:
- Q9UIS9
- Synonyms:
- CXXC-type zinc finger protein 3;CXXC3;methyl-CpG-binding domain protein 1;Methyl-CpG-binding protein MBD1;PCM1;protein containing methyl-CpG-binding domain 1;RFT;the regulator of fibroblast growth factor 2 (FGF-2) transcription
- Extra Details:
- DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. [provided by RefSeq]
- Shipping Conditions:
- Blue Ice