GTX133347
OTUB1 antibody
Cannot supply to this region.
- SKU:
- GTX133347
- Additional Names:
- OTU domain, ubiquitin aldehyde binding 1 , AI850305
- Application:
- WB, IF, ICC
- Concentration:
- 0.51 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Mouse
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Buffer:
- PBS, 20% Glycerol, 0.025% ProClin 300.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of mouse OTUB1. The exact sequence is proprietary.
- Uniprot:
- Q7TQI3
- Synonyms:
- AI850305;deubiquitinating enzyme OTUB1;OTU domain-containing ubiquitin aldehyde-binding protein 1;otubain 1;Otubain-1;ubiquitin thioesterase OTUB1;ubiquitin-specific-processing protease OTUB1
- Extra Details:
- Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a nuch lower preference compared to 'Lys-48'-linked ubiquitin.
- Shipping Conditions:
- Blue Ice