GTX133192
PTEN (phospho Ser380) antibody
Cannot supply to this region.
- SKU:
- GTX133192
- Additional Names:
- phosphatase and tensin homolog , 10q23del , BZS , CWS1 , DEC , GLM2 , MHAM , MMAC1 , PTEN1 , PTENbeta , TEP1
- Application:
- WB
- Concentration:
- 0.17 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human, Mouse
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Buffer:
- PBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300.
- Immunogen:
- Carrier-protein conjugated synthetic peptide surrounding phospho Ser380 of human PTEN. The exact sequence is proprietary.
- Uniprot:
- P60484
- Synonyms:
- 10q23del;BZS;CWS1;DEC;GLM2;MHAM;mitochondrial phosphatase and tensin protein alpha;mitochondrial PTENalpha;MMAC1;MMAC1 phosphatase and tensin homolog deleted on chromosome 10;mutated in multiple advanced cancers 1;Phosphatase and tensin homolog;phosphatase and tensin-like protein;phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;protein tyrosine phosphatase;PTEN variant PTEN-K267Rfs*9;PTEN variant PTEN-L247*;PTEN variant PTEN-R234Afs*11;PTEN1;PTENbeta;PTENepsilon;TEP1
- Extra Details:
- This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq]
- Shipping Conditions:
- Blue Ice