GTX132309
USP20 antibody
Cannot supply to this region.
- SKU:
- GTX132309
- Additional Names:
- ubiquitin specific peptidase 20 , LSFR3A , VDU2 , hVDU2
- Application:
- WB
- Concentration:
- 0.98 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 20% Glycerol, 0.025% ProClin 300.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human USP20. The exact sequence is proprietary.
- Uniprot:
- Q9Y2K6
- Synonyms:
- deubiquitinating enzyme 20;hVDU2;LSFR3A;pVHL-interacting deubiquitinating enzyme 2;ubiquitin carboxyl-terminal hydrolase 20;ubiquitin thioesterase 20;ubiquitin thiolesterase 20;ubiquitin-specific-processing protease 20;VDU2;VHL-interacting deubiquitinating enzyme 2
- Extra Details:
- Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
- Shipping Conditions:
- Blue Ice