GTX129022
CIITA antibody
Cannot supply to this region.
- SKU:
- GTX129022
- Additional Names:
- class II major histocompatibility complex transactivator , C2TA , CIITAIV , MHC2TA , NLRA
- Application:
- WB
- Concentration:
- 1.31 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 20% Glycerol, 0.025% ProClin 300.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human CIITA. The exact sequence is proprietary.
- Uniprot:
- P33076
- Synonyms:
- C2TA;CIITAIV;MHC class II transactivator;MHC class II transactivator type I;MHC class II transactivator type III;MHC2TA;NLR family, acid domain containing;NLRA;nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
- Extra Details:
- This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq]
- Shipping Conditions:
- Blue Ice