DAG1 / beta Dystroglycan antibody [C2C3-2], C-term

Cannot supply to this region.

SKU:: GTX124225
Additional Names:: dystroglycan 1 , 156DAG , A3a , AGRNR , DAG , LGMDR16 , MDDGA9 , MDDGC7 , MDDGC9
Application:: WB, IHC-P, IF, ICC
Concentration:: 0.6 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse
Buffer:: PBS, 20% Glycerol, 0.025% ProClin 300.
Immunogen:: Recombinant protein encompassing a sequence within the C-terminus region of human DAG1 / beta Dystroglycan. The exact sequence is proprietary.
Clone:: C2C3-2
Uniprot:: Q14118
Synonyms:: 156DAG;A3a;AGRNR;DAG;dystroglycan;dystroglycan 1 (dystrophin-associated glycoprotein 1);Dystrophin-associated glycoprotein 1;LGMDR16;MDDGA9;MDDGC7;MDDGC9
Extra Details:: Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. [provided by RefSeq]

Shipping Conditions:: Blue Ice