GTX123277
MRVI1 antibody
Cannot supply to this region.
- SKU:
- GTX123277
- Additional Names:
- murine retrovirus integration site 1 homolog , IRAG , JAW1L
- Application:
- WB, IHC-P
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 1% BSA, 20% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Recombinant protein encompassing a sequence within the C-terminus region of human MRVI1. The exact sequence is proprietary.
- Uniprot:
- Q9Y6F6
- Synonyms:
- inositol 1,4,5-triphosphate receptor associated 1;inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate;inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate;IP3R-associated cGMP kinase substrate;IRAG;JAW1-related protein MRVI1;JAW1L;MRVI1;murine retrovirus integration site 1 homolog
- Extra Details:
- This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during lymphoid differentiation. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, few of which initiate translation at a non-AUG (CUG) start site. [provided by RefSeq]
- Shipping Conditions:
- Blue Ice