GTX12024
NOX2 / gp91phox antibody
Cannot supply to this region.
- SKU:
- GTX12024
- Application:
- WB, IHC-P
- Concentration:
- 500 ug/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.1% Na₂HPO₄, 0.45% NaCl, 2.5% BSA, 0.025% Thimerosal, 0.025% Sodium azide.
- Immunogen:
- A synthetic peptide corresponding to a sequence in the middle region of human NOX2(442-459aa YWLCRDTHAFEWFADLLQ), identical to the related rat and mouse sequences.
- Uniprot:
- P04839
- Synonyms:
- AMCBX2;CGD;CGD91-phox;CGDX;cytochrome b-245 beta polypeptide;cytochrome b-245 heavy chain;cytochrome b(558) subunit beta;cytochrome b558 subunit beta;GP91-1;GP91-PHOX;GP91PHOX;heme-binding membrane glycoprotein gp91phox;IMD34;NADPH oxidase 2;neutrophil cytochrome b 91 kDa polypeptide;NOX2;p22 phagocyte B-cytochrome;p91-PHOX;superoxide-generating NADPH oxidase heavy chain subunit
- Extra Details:
- Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]
- Shipping Conditions:
- Blue Ice