SETD8 antibody

Cannot supply to this region.

SKU:: GTX119440
Additional Names:: lysine methyltransferase 5A , PR-Set7 , PR/SET07 , SET07 , SET8 , SETD8
Application:: WB, IF, ICC
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: 0.1M Tris, 0.1M Glycine, 20% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human SETD8. The exact sequence is proprietary.
Uniprot:: Q9NQR1
Synonyms:: H4-K20-HMTase KMT5A;H4-K20-HMTase SETD8;H4-K20-specific histone methyltransferase;H4K20-specific histone methyltransferase splice variant Set8b;histone-lysine N-methyltransferase KMT5A;histone-lysine N-methyltransferase SETD8;lysine (K)-specific methyltransferase 5A;lysine N-methyltransferase 5A;lysine-specific methylase 5A;N-lysine methyltransferase KMT5A;N-lysine methyltransferase SETD8;PR-Set7;PR/SET domain containing protein 8;PR/SET domain-containing protein 07;PR/SET07;SET domain containing (lysine methyltransferase) 8;SET domain-containing protein 8;SET07;SET8;SETD8
Extra Details:: Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones.

Shipping Conditions:: Blue Ice