4-1BBL / CD137L antibody [N2C3]

Cannot supply to this region.

SKU:: GTX117355
Additional Names:: TNF superfamily member 9 , 4-1BB-L , CD137L , TNLG5A
Application:: WB, IP
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: 0.1M Tris, 0.1M Glycine, 20% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the Extracellular domain of human TNFSF9. The exact sequence is proprietary.
Clone:: N2C3
Uniprot:: P41273
Synonyms:: 4-1BB ligand;4-1BB-L;4-1BBL;CD137 ligand;CD137L;homolog of mouse 4-1BB-L;receptor 4-1BB ligand;TNLG5A;tumor necrosis factor (ligand) superfamily, member 9;tumor necrosis factor ligand 5A;tumor necrosis factor ligand superfamily member 9;tumor necrosis factor superfamily member 9
Extra Details:: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.

Shipping Conditions:: Blue Ice