ITM2C antibody

Cannot supply to this region.

SKU:: GTX116904
Additional Names:: integral membrane protein 2C , BRI3 , BRICD2C , E25 , E25C , ITM3
Application:: Flow Cytometry, WB, IHC-P
Concentration:: 0.7 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: 0.1M Tris, 0.1M Glycine, 20% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human ITM2C. The exact sequence is proprietary.
Uniprot:: Q9NQX7
Synonyms:: BRI3;BRICD2C;BRICHOS domain containing 2C;cerebral protein 14;E25;E25C;integral membrane protein 2C;integral membrane protein 3;ITM3;transmembrane protein BRI3
Extra Details:: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.