GIT2 antibody [N1N3]

Cannot supply to this region.

SKU:: GTX116427
Additional Names:: GIT ArfGAP 2 , CAT-2 , CAT2 , PKL
Application:: WB, IHC-Fr, IF, ICC
Concentration:: 0.81 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse
Buffer:: 0.1M Tris, 0.1M Glycine, 20% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human GIT2. The exact sequence is proprietary.
Clone:: N1N3
Uniprot:: Q14161
Synonyms:: ARF GAP GIT2;ARF GTPase-activating protein GIT2;CAT-2;CAT2;cool-associated, tyrosine phosphorylated protein 2;cool-interacting tyrosine-phosphorylated protein 2;G protein-coupled receptor kinase interacting ArfGAP 2;G protein-coupled receptor kinase-interactor 2;GRK-interacting protein 2;Paxillin kinase linker;PKL
Extra Details:: This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq]

Shipping Conditions:: Blue Ice