![CHFR antibody [C1C3]](https://www.genetex.com/upload/website/prouct_img/normal/GTX116262/GTX116262_40408_WB_w_23060519_581.webp)
GTX116262
CHFR antibody [C1C3]
Cannot supply to this region.
- SKU:
- GTX116262
- Additional Names:
- checkpoint with forkhead and ring finger domains , RNF116 , RNF196
- Application:
- WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 1% BSA, 20% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human CHFR. The exact sequence is proprietary.
- Clone:
- C1C3
- Uniprot:
- Q96EP1
- Synonyms:
- Checkpoint with forkhead and RING finger domains protein;checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase;E3 ubiquitin-protein ligase CHFR;RING finger protein 196;RING-type E3 ubiquitin transferase CHFR;RNF116;RNF196
- Extra Details:
- E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.
- Shipping Conditions:
- Blue Ice