![NARF antibody [N3C2], Internal](https://www.genetex.com/upload/website/prouct_img/normal/GTX115821/GTX115821_40807_IFA_w_23060519_680.webp)
![NARF antibody [N3C2], Internal](https://www.genetex.com/upload/website/prouct_img/normal/GTX115821/GTX115821_40807_IHC_M_w_23060519_853.webp)
![NARF antibody [N3C2], Internal](https://www.genetex.com/upload/website/prouct_img/normal/GTX115821/GTX115821_40807_WB_w_23060519_430.webp)
GTX115821
NARF antibody [N3C2], Internal
Cannot supply to this region.
- SKU:
- GTX115821
- Additional Names:
- nuclear prelamin A recognition factor , IOP2
- Application:
- WB, IHC-P, IF, ICC
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- PBS, 1% BSA, 20% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human NARF. The exact sequence is proprietary.
- Clone:
- N3C2
- Uniprot:
- Q9UHQ1
- Synonyms:
- IOP2;iron-only hydrogenase-like protein 2;nuclear prelamin A recognition factor;prenyl-dependent prelamin A binding protein
- Extra Details:
- Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq]
- Shipping Conditions:
- Blue Ice