CPSF4 antibody [N1C3]

Cannot supply to this region.

SKU:: GTX115498
Additional Names:: cleavage and polyadenylation specific factor 4 , CPSF30 , NAR , NEB-1 , NEB1
Application:: WB
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS, 1% BSA, 20% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human CPSF4. The exact sequence is proprietary.
Clone:: N1C3
Uniprot:: O95639
Synonyms:: cleavage and polyadenylation specific factor 4, 30kDa;cleavage and polyadenylation specificity factor 30 kDa subunit;cleavage and polyadenylation specificity factor subunit 4;CPSF 30 kDa subunit;CPSF30;NAR;NEB-1;NEB1;no arches homolog;no arches-like zinc finger protein;NS1 effector domain-binding protein 1
Extra Details:: Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq]

Shipping Conditions:: Blue Ice