![GALE antibody [N2C3]](https://www.genetex.com/upload/website/prouct_img/normal/GTX114419/GTX114419_WB_w_23060501_793.webp)
GTX114419
GALE antibody [N2C3]
Cannot supply to this region.
- SKU:
- GTX114419
- Additional Names:
- UDP-galactose-4-epimerase , SDR1E1
- Application:
- WB
- Concentration:
- 0.58 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 0.1M Tris, 0.1M Glycine, 20% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human GALE. The exact sequence is proprietary.
- Clone:
- N2C3
- Uniprot:
- Q14376
- Synonyms:
- epididymis secretory sperm binding protein;galactose-4-epimerase, UDP-;galactowaldenase;SDR1E1;short chain dehydrogenase/reductase family 1E, member 1;UDP galactose-4'-epimerase;UDP-galactose 4-epimerase;UDP-GalNAc 4-epimerase;UDP-GlcNAc 4-epimerase;UDP-glucose 4-epimerase;UDP-N-acetylgalactosamine 4-epimerase;UDP-N-acetylglucosamine 4-epimerase
- Extra Details:
- This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq]
- Shipping Conditions:
- Blue Ice