MSH3 antibody [C2C3], C-term

Cannot supply to this region.

SKU:: GTX113781
Additional Names:: mutS homolog 3 , DUP , FAP4 , MRP1
Application:: WB, IHC-P, IF, ICC
Concentration:: 1.79 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS, 20% Glycerol, 0.025% ProClin 300.
Immunogen:: Recombinant protein encompassing a sequence within the C-terminus region of human MSH3. The exact sequence is proprietary.
Clone:: C2C3
Uniprot:: P20585
Synonyms:: divergent upstream protein;DNA mismatch repair protein Msh3;DUP;epididymis secretory sperm binding protein;FAP4;hMSH3;mismatch repair protein 1;MRP1
Extra Details:: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.