GTX113667
Cytochrome P450 2D6 antibody
Cannot supply to this region.
- SKU:
- GTX113667
- Additional Names:
- cytochrome P450 family 2 subfamily D member 6 , CPD6 , CYP2D , CYP2D7AP , CYP2D7BP , CYP2D7P2 , CYP2D8P2 , CYP2DL1 , CYPIID6 , P450-DB1 , P450C2D , P450DB1
- Application:
- WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 0.1M Tris, 0.1M Glycine, 20% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human Cytochrome P450 2D6. The exact sequence is proprietary.
- Uniprot:
- P10635
- Synonyms:
- cholesterol 25-hydroxylase;CPD6;CYP2D;CYP2D7AP;CYP2D7BP;CYP2D7P2;CYP2D8P2;CYP2DL1;CYPIID6;cytochrome P450 2D6;cytochrome P450-DB1;cytochrome P450, family 2, subfamily D, polypeptide 6;cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2;cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2;cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2;cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2;cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1;cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6;debrisoquine 4-hydroxylase;flavoprotein-linked monooxygenase;microsomal monooxygenase;nonfunctional cytochrome P450 2D6;P450-DB1;P450C2D;P450DB1;xenobiotic monooxygenase
- Extra Details:
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Shipping Conditions:
- Blue Ice