CD42c antibody [N2C2], Internal

Cannot supply to this region.

SKU:: GTX113355
Additional Names:: glycoprotein Ib platelet subunit beta , BDPLT1 , BS , CD42C , GPIBB , GPIbbeta
Application:: WB
Concentration:: 0.75 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse
Buffer:: 0.1M Tris, 0.1M Glycine, 10% Glycerol, 0.01% Thimerosal.
Immunogen:: Synthetic peptide encompassing a sequence within the Extracellular domain of human CD42c. The exact sequence is proprietary.
Clone:: N2C2
Uniprot:: P13224
Synonyms:: antigen CD42b-beta;BDPLT1;BS;CD42C;glycoprotein Ib (platelet), beta polypeptide;glycoprotein Ib platelet beta subunit;GP-Ib beta;GPIBB;GPIbbeta;nuclear localization signal deleted in velocardiofacial syndrome;platelet glycoprotein Ib beta chain;platelet membrane glycoprotein Ib beta;truncated platelet membrane glycoprotein Ib beta
Extra Details:: Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal within a separate gene (septin 5) located upstream of this gene. In the absence of polyadenylation from its own imperfect site, the septin 5 gene uses the consensus polyA signal of this gene. [provided by RefSeq]

Shipping Conditions:: Blue Ice