![DNA polymerase iota antibody [N3C2], Internal](https://www.genetex.com/upload/website/prouct_img/normal/GTX112583/GTX112583_45385_20240419_WB_TPM_watermark_24043002_193.webp)
![DNA polymerase iota antibody [N3C2], Internal](https://www.genetex.com/upload/website/prouct_img/normal/GTX112583/GTX112583_45385_20240816_WB_M_R_24082301_384.webp)
GTX112583
DNA polymerase iota antibody [N3C2], Internal
Cannot supply to this region.
- SKU:
- GTX112583
- Additional Names:
- DNA polymerase iota , RAD30B , RAD3OB , eta2
- Application:
- WB
- Concentration:
- 0.34 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 1% BSA, 20% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human DNA polymerase iota. The exact sequence is proprietary.
- Clone:
- N3C2
- Uniprot:
- Q9UNA4
- Synonyms:
- DNA polymerase iota;eta2;polymerase (DNA directed) iota;polymerase (DNA-directed), iota;polymerase (DNA) iota;RAD30 homolog B;RAD30B;RAD3OB
- Extra Details:
- Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
- Shipping Conditions:
- Blue Ice