GTX112342
eIF3e antibody
Cannot supply to this region.
- SKU:
- GTX112342
- Additional Names:
- eukaryotic translation initiation factor 3 subunit E , EIF3-P48 , EIF3S6 , INT6 , eIF3-p46
- Application:
- WB, IHC-P, IF, ICC
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- PBS, 1% BSA, 20% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human eIF3e. The exact sequence is proprietary.
- Uniprot:
- P60228
- Synonyms:
- eIF-3 p48;eIF3-p46;EIF3-P48;EIF3S6;eukaryotic translation initiation factor 3 subunit 6;eukaryotic translation initiation factor 3 subunit E;eukaryotic translation initiation factor 3, subunit 6 (48kD);eukaryotic translation initiation factor 3, subunit 6 48kDa;INT6;mammary tumor-associated protein INT6;murine mammary tumor integration site 6 (oncogene homolog);viral integration site protein INT-6 homolog
- Extra Details:
- Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
- Shipping Conditions:
- Blue Ice