Dbs antibody [N1N2], N-term

Cannot supply to this region.

SKU:: GTX112306
Additional Names:: MCF.2 cell line derived transforming sequence like , ARHGEF14 , DBS , OST
Application:: WB
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: 0.1M Tris, 0.1M Glycine, 10% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the N-terminus region of human Dbs. The exact sequence is proprietary.
Clone:: N1N2
Uniprot:: O15068
Synonyms:: ARHGEF14;DBL's big sister;DBS;guanine nucleotide exchange factor DBS;MCF2 transforming sequence-like protein;MCF2-transforming sequence-like protein;OST
Extra Details:: Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42.