Bcr antibody [C2C3-2], C-term

Cannot supply to this region.

SKU:: GTX111591
Additional Names:: BCR activator of RhoGEF and GTPase , ALL , BCR1 , CML , D22S11 , D22S662 , PHL
Application:: WB, IHC-P
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: 0.1M Tris, 0.1M Glycine, 10% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the C-terminus region of human Bcr. The exact sequence is proprietary.
Clone:: C2C3-2
Uniprot:: P11274
Synonyms:: ALL;BCR, RhoGEF and GTPase activating protein;BCR/FGFR1 chimera protein;BCR1;breakpoint cluster region;breakpoint cluster region protein;CML;D22S11;D22S662;FGFR1/BCR chimera protein;PHL;renal carcinoma antigen NY-REN-26
Extra Details:: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Shipping Conditions:: Blue Ice