MEKK3 antibody [N3C2], Internal

Cannot supply to this region.

SKU:: GTX111498
Additional Names:: mitogen-activated protein kinase kinase kinase 3 , MAPKKK3 , MEKK3
Application:: WB, IHC-P
Concentration:: 0.72 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: 0.1M Tris, 0.1M Glycine, 20% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human MEKK3. The exact sequence is proprietary.
Clone:: N3C2
Uniprot:: Q99759
Synonyms:: MAP/ERK kinase kinase 3;MAPK/ERK kinase kinase 3;MAPKKK3;MEK kinase 3;MEKK 3;MEKK3;mitogen-activated protein kinase kinase kinase 3
Extra Details:: This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]

Shipping Conditions:: Blue Ice