GTX11148
Presenilin 2 antibody
Cannot supply to this region.
- SKU:
- GTX11148
- Additional Names:
- presenilin 2 , AD3L , AD4 , CMD1V , PS2 , STM2
- Application:
- ELISA, IHC-P, IHC-Fr
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Crude Serum
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Goat
- Reactivities:
- Human, Mouse
- Buffer:
- Serum, 0.1% Sodium azide.
- Immunogen:
- Synthetic peptide corresponding to amino acids 31-47 of Presenilin-2
- Uniprot:
- P49810
- Synonyms:
- AD3L;AD3LP;AD4;AD5;Alzheimer disease 4;CMD1V;E5-1;presenilin-2;PS-2;PS2;STM-2;STM2
- Extra Details:
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
- Shipping Conditions:
- Blue Ice