GTX111200
FZR1 antibody
Cannot supply to this region.
- SKU:
- GTX111200
- Additional Names:
- fizzy and cell division cycle 20 related 1 , CDC20C , CDH1 , FZR , FZR2 , HCDH , HCDH1
- Application:
- WB, IHC-P, IF, ICC
- Concentration:
- 0.26 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human FZR1. The exact sequence is proprietary.
- Uniprot:
- Q9UM11
- Synonyms:
- CDC20 homolog 1;CDC20-like 1b;CDC20-like protein 1;CDC20C;CDH1;cdh1/Hct1 homolog;fizzy-related protein homolog;fizzy/cell division cycle 20 related 1;FZR;FZR2;HCDH;HCDH1
- Extra Details:
- Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
- Shipping Conditions:
- Blue Ice