GTX11066
Cortactin antibody
Cannot supply to this region.
- SKU:
- GTX11066
- Additional Names:
- cortactin , EMS1
- Application:
- WB, IF, ICC
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 15mM Sodium azide.
- Immunogen:
- synthetic peptide corresponding to the mid-region of human cortactin (amino acids 361-380) conjugated to KLH.
- Uniprot:
- Q14247
- Synonyms:
- 1110020L01Rik;amplaxin;EMS1;ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate);epididymis secretory sperm binding protein;oncogene EMS1;src substrate cortactin
- Extra Details:
- Cortactin is an 80/85 kDa cytoskeleton protein that facilitates assembly of cortical actin. Cortactin is widely expressed in most adherent cells and is a prominent substrate of protein-tyrosine kinase Src in vivo and in vitro. The protein sequence of cortactin contains multiple amino-terminal tandem repeats of a unique 37-amino acid sequence, which associates with actin, and a Src homology 3 (SH3) domain at the carboxyl terminus. Between the repeat and the SH3 domain, there is an alpha-helical structure followed by a proline-rich region. Between the proline-rich region and the SH3 domain, there are a series of Src phosphorylation sites (Tyr-421, Tyr-470, and Tyr-486). In vitro, cortactin binds to and cross-links F-actin into meshworks.
- Shipping Conditions:
- Blue Ice