MBD1 antibody [N2C2], Internal

Cannot supply to this region.

SKU:: GTX110612
Additional Names:: methyl-CpG binding domain protein 1 , CXXC3 , PCM1 , RFT
Application:: WB
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS, 1% BSA, 20% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human MBD1. The exact sequence is proprietary.
Clone:: N2C2
Uniprot:: Q9UIS9
Synonyms:: CXXC-type zinc finger protein 3;CXXC3;methyl-CpG-binding domain protein 1;Methyl-CpG-binding protein MBD1;PCM1;protein containing methyl-CpG-binding domain 1;RFT;the regulator of fibroblast growth factor 2 (FGF-2) transcription
Extra Details:: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21. [provided by RefSeq]

Shipping Conditions:: Blue Ice