GTX110497
PIASy antibody
Cannot supply to this region.
- SKU:
- GTX110497
- Additional Names:
- protein inhibitor of activated STAT 4 , PIAS-gamma , PIASY , Piasg , ZMIZ6
- Application:
- WB, IHC-P, IF, ICC
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 0.1M Tris, 0.1M Glycine, 10% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human PIASy. The exact sequence is proprietary.
- Uniprot:
- Q8N2W9
- Synonyms:
- E3 SUMO-protein ligase PIAS4;PIAS-gamma;Piasg;PIASY;protein inhibitor of activated STAT protein 4;protein inhibitor of activated STAT protein gamma;protein inhibitor of activated STAT protein PIASy;RING-type E3 ubiquitin transferase PIAS4;zinc finger, MIZ-type containing 6;ZMIZ6
- Extra Details:
- Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.
- Shipping Conditions:
- Blue Ice