GTX10988
Glucagon antibody [K79bB10]
Cannot supply to this region.
- SKU:
- GTX10988
- Additional Names:
- glucagon , GLP-1 , GLP1 , GLP2 , GRPP
- Application:
- IHC, RIA, IHC-P, IF, ICC, Dot blot
- Physical State:
- Liquid
- Species Reactivity:
- Porcine
- Purification:
- Unpurified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Mouse
- Reactivities:
- Canine, Human, Mouse, Porcine, Rabbit, Rat, Feline, Guinea Pig
- Buffer:
- Ascites, 15mM Sodium azide.
- Immunogen:
- Polymerized porcine glucagon.
- Clone:
- K79bB10
- Uniprot:
- P01275
- Synonyms:
- glicentin-related polypeptide;GLP-1;GLP1;GLP2;glucagon-like peptide 1;glucagon-like peptide 2;GRPP;preproglucagon;pro-glucagon
- Extra Details:
- Glucagon is a 29-residue polypeptide hormone (MW 3482), produced in the pancreas. A related hormone, enteroglucagon (or oxyntomodulin), which is produced in the mucosa of the small and large intestine, consists of the 29 amino acid sequence of pancreatic glucagon extended by 8 additional residues at the C-terminus. The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis, and ketogenesis, which are antagonistic effects to those of insulin action, thus leading to increased blood glucose levels. Immunocytochemical studies have revealed the presence of pancreatic glucagon inside the A or alpha cells, which constitute 15-20% of the islet cell population. These cells are located preferentially at the periphery of the human pancreatic islets. Pathological manifestations of the glucagon-type peptide reside almost exclusively with the existence of tumors or glucagonomas, as no states of glucagon-cell deficiency or hyperplasia have been identified. Glucagon-specific antibodies would prove useful as an cell and tumor markers applying immunohistochemical techniques, and as an analytical tool in quantification of the hormone.
- Shipping Conditions:
- Blue Ice