CCM2 antibody [N1C2]

Cannot supply to this region.

SKU:: GTX109835
Additional Names:: CCM2 scaffold protein , C7orf22 , OSM , PP10187
Application:: WB
Concentration:: 0.4 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS, 1% BSA, 20% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human CCM2. The exact sequence is proprietary.
Clone:: N1C2
Uniprot:: Q9BSQ5
Synonyms:: C7orf22;CCM2 scaffolding protein;cerebral cavernous malformation 2;cerebral cavernous malformations 2 protein;malcavernin;OSM;osmosensing scaffold for MEKK3;PP10187
Extra Details:: This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Shipping Conditions:: Blue Ice