GTX10854
TGF beta Receptor III antibody
Cannot supply to this region.
- SKU:
- GTX10854
- Additional Names:
- transforming growth factor beta receptor 3 , BGCAN , betaglycan
- Application:
- ELISA, WB
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Goat
- Reactivities:
- Human
- Buffer:
- PBS carbohydrates, no preservatives.
- Immunogen:
- recombinant human TGF-B Beta sRIII (betaglycan) expressed in NSO cells
- Uniprot:
- Q03167
- Synonyms:
- betaglycan;betaglycan proteoglycan;BGCAN;TGF-beta receptor type 3;TGF-beta receptor type III;TGFR-3;transforming growth factor beta receptor III;transforming growth factor beta receptor type 3
- Extra Details:
- Most mammalian cells express three abundant high affinity receptors, which can bind and be cross-linked to TGF beta: the type I (53 kDa), type II (65 kDa), and type III (100-280 kDa) receptors, based upon the molecular mass of the cross-linked products analyzed by gel electrophoresis. Tbeta-RI and Tbeta-RII, the type I and II receptors, are type I transmembrane proteins with cytosolic domains containing a serine-threonine kinase. Both receptors are essential for signal transduction. The TGF beta type III receptor, or betaglycan, is a membrane-bound proteoglycan with a short cytoplasmic tail that has no apparent signaling motif. It binds TGF beta 2 (apparent Kd 100 pM) with slightly greater affinity than TGF beta 1 or TGF beta 3 (apparent Kda 300 pM). The main role of betaglycan seems to be in binding and then presenting TGF beta ligand to the signaling receptors Tbeta-RI and Tbeta-RII; overexpression of Tbeta-RIII in L6 myoblasts leads to a dramatic increase in TGF beta 2 binding to Tbeta-RI and Tbeta-RII.
- Shipping Conditions:
- Blue Ice