HLA-DMB antibody [C2C3], C-term

Cannot supply to this region.

SKU:: GTX108492
Additional Names:: major histocompatibility complex, class II, DM beta , D6S221E , RING7
Application:: WB, IHC-P
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: 0.1M Tris, 0.1M Glycine, 10% Glycerol, 0.01% Thimerosal.
Immunogen:: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human HLA-DMB. The exact sequence is proprietary.
Clone:: C2C3
Uniprot:: P28068
Synonyms:: class II histocompatibility antigen, M beta chain;D6S221E;HLA class II histocompatibility antigen, DM beta chain;MHC class II antigen DMB;MHC class II antigen HLA-DM beta chain;MHC class II HLA-DMB;really interesting new gene 7 protein;RING7
Extra Details:: HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq]

Shipping Conditions:: Blue Ice