GTX10745
Interferon gamma Receptor 1 antibody
Cannot supply to this region.
- SKU:
- GTX10745
- Additional Names:
- interferon gamma receptor 1 , CD119 , IFNGR , IMD27A , IMD27B
- Application:
- ELISA, WB, IF, ICC, Neutralisation
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Goat
- Reactivities:
- Human
- Buffer:
- PBS carbohydrates, no preservatives.
- Immunogen:
- recombinant human IFN-G Gamma Receptor I extracellular domain expressed in NSO cells.
- Uniprot:
- P15260
- Synonyms:
- antiviral protein, type 2;AVP, type 2;CD119;CD119 antigen;CDw119;IFN-gamma receptor 1;IFN-gamma-R-alpha;IFN-gamma-R1;IFNGR;IMD27A;IMD27B;immune interferon receptor 1;interferon gamma receptor 1;Interferon gamma receptor alpha-chain;interferon-gamma receptor alpha chain
- Extra Details:
- The IFNG receptor complex is composed of two type I membrane proteins, IFNGRI (IFNGR alpha) and IFNGR2 (IFNGR beta). Both receptor proteins are members of the type II cytokine receptor family and share 52% overall sequence identity. The IFNG receptor is constitutively expressed in most cell types. Soluble IFNG has been detected in biological fluids. IFNG R1 is required for ligand-binding and signaling. It binds to IFNG with high affinity and is a potent IFNG antagonist. In signal transduction, IFNG induces tyrosine phosphorylation of IFNG R1 leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFNg-induced gene transcription. Human IFNGRI, a 227 amino acid residue protein, has a calculated molecular mass of approximately 25 kDa. As a result of glycosylation, the recombinant IFNGRI migrates as a 40 to 50 kDa protein in SDS-PAGE. Human and mouse IFNGRI share approximately 52% amino acid sequence identity and each interacts with IFNG in a strictly species-specific manner.
- Shipping Conditions:
- Blue Ice