DENND1B antibody [N1C1]

Cannot supply to this region.

SKU:: GTX107160
Additional Names:: DENN domain containing 1B , C1ORF18 , C1orf218 , FAM31B
Application:: WB, IF, ICC
Concentration:: 0.9 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse
Buffer:: 0.1M Tris, 0.1M Glycine, 10% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human DENND1B. The exact sequence is proprietary.
Clone:: N1C1
Uniprot:: Q6P3S1
Synonyms:: C1ORF18;C1orf218;connecdenn 2;DENN domain-containing protein 1B;DENN/MADD domain containing 1B;FAM31B;family with sequence similarity 31, member B;Protein FAM31B
Extra Details:: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM]