GTX107080
Siglec 7 antibody
Cannot supply to this region.
- SKU:
- GTX107080
- Additional Names:
- sialic acid binding Ig like lectin 7 , AIRM1 , CD328 , CDw328 , D-siglec , QA79 , SIGLEC-7 , SIGLEC19P , SIGLECP2 , p75 , p75/AIRM1
- Application:
- WB, IHC-P, IF, ICC
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 1% BSA, 20% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human Siglec 7. The exact sequence is proprietary.
- Uniprot:
- Q9Y286
- Synonyms:
- Adhesion inhibitory receptor molecule 1;adhesion inhibitory receptor molecule 1, siglec-7;AIRM-1;AIRM1;CD328;CDw328;D-siglec;p75;p75/AIRM1;QA79;QA79 membrane protein;sialic acid binding immunoglobulin-like lectin 7;sialic acid-binding Ig-like lectin 7;SIGLEC-7;SIGLEC19P;SIGLECP2
- Extra Details:
- Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
- Shipping Conditions:
- Blue Ice