GTX105711
Nkx2.5 antibody
Cannot supply to this region.
- SKU:
- GTX105711
- Additional Names:
- NK2 homeobox 5 , CHNG5 , CSX , CSX1 , HLHS2 , NKX2.5 , NKX2E , NKX4-1 , VSD3
- Application:
- WB, IHC-P, IF, ICC
- Concentration:
- 1.15 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 20% Glycerol, 0.025% ProClin 300.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human Nkx2.5. The exact sequence is proprietary.
- Uniprot:
- P52952
- Synonyms:
- Cardiac-specific homeobox;cardiac-specific homeobox 1;CHNG5;CSX;CSX1;HLHS2;homeobox protein CSX;homeobox protein NK-2 homolog E;homeobox protein NKX 2-5;homeobox protein Nkx-2.5;NK2 transcription factor related, locus 5;NKX 2-5;NKX2.5;NKX2E;NKX4-1;tinman homolog;tinman paralog;VSD3
- Extra Details:
- Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation, as well as determining the temporal and spatial patterns of development (Shiojima et al., 1995 [PubMed 7665173]). It has been demonstrated that a Drosophila homeobox-containing gene called 'tinman' is expressed in the developing dorsal vessel and in the equivalent of the vertebrate heart. Mutations in tinman result in loss of heart formation in the embryo, suggesting that tinman is essential for Drosophila heart formation. Furthermore, abundant expression of Csx, the presumptive mouse homolog of tinman, is observed only in the heart from the time of cardiac differentiation. CSX, the human homolog of murine Csx, has a homeodomain sequence identical to that of Csx and is expressed only in the heart, again suggesting that CSX plays an important role in human heart formation.[supplied by OMIM]
- Shipping Conditions:
- Blue Ice