GTX10493
LTBR antibody
Cannot supply to this region.
- SKU:
- GTX10493
- Additional Names:
- lymphotoxin beta receptor , D12S370 , LT-BETA-R , TNF-R-III , TNFCR , TNFR-RP , TNFR2-RP , TNFR3 , TNFRSF3
- Application:
- Flow Cytometry, WB
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Goat
- Reactivities:
- Human
- Buffer:
- PBS carbohydrates, no preservatives.
- Immunogen:
- recombinant human lymphotoxin B Beta receptor extracellular domain expressed in NS0 cells.
- Uniprot:
- P36941
- Synonyms:
- D12S370;LT-BETA-R;lymphotoxin B receptor;lymphotoxin beta receptor (TNFR superfamily, member 3);Lymphotoxin-beta receptor;TNF-R-III;TNFCR;TNFR-RP;TNFR2-RP;TNFR3;TNFRSF3;tumor necrosis factor C receptor;tumor necrosis factor receptor 2-related protein;tumor necrosis factor receptor superfamily member 3;tumor necrosis factor receptor type III
- Extra Details:
- Tumor necrosis factor-beta (TNF-beta), also known as lymphotoxin (LT or LT-a) and cytotoxic factor, is a 25 kDa glycoprotein that is tightly regulated by lymphocytes. TNF-beta and TNF-alpha share a 28% amino acid sequence identity, and as soluble forms, both can exist in solution as homotrimers, activate the same TNF receptors (TNFR1 and TNFR2) and elicit many of the same bioactivities. Unlike TNF-alpha, TNF-beta can also form heterotrimers with one or two molecules of the related membrane-bound lymphotoxin-beta (LT-beta). Reportedly, LT-alpha1/beta2, the predominant heterotrimer, binds and activates only the LT-beta receptor, LT-betaR. The other heterotrimer, LT-alpha2/beta1 binds and activates TNFR1 and TNFR2 but not LT-betaR. TNF-beta is expressed in activated T, B and NK cells and in certain transformed cells. Genes for TNF-beta, LT-beta and TNF-alpha are tightly linked near each other within the MHC. TNF-beta appears to play many of the same biological roles as TNF-alpha, but the membrane-bound form with LT-beta is critical for normal lymphoid organ development. Genetic polymorphisms in TNF-alpha and TNF-beta have been linked to certain pathological conditions, including myasthenia gravis. At the amino acid level, human and mouse TNF-beta are 74% homologous and human and mouse LT-beta are 80% homologous.
- Shipping Conditions:
- Blue Ice