GTX10455
Caspase 12 antibody [14F7]
Cannot supply to this region.
- SKU:
- GTX10455
- Additional Names:
- caspase 12
- Application:
- IHC, WB, IF, ICC, IP
- Physical State:
- Liquid
- Species Reactivity:
- Mouse
- Purification:
- Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rat
- Reactivities:
- Mouse, Rat
- Buffer:
- PBS, 15mM Sodium azide.
- Immunogen:
- recombinant mouse caspase 12 (residues 95-318).
- Clone:
- 14F7
- Uniprot:
- O08736
- Synonyms:
- CASP-12;caspase-12
- Extra Details:
- Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main ways in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is colocalized to the ER with several proteins that are involved in Alzheimer s disease including g-secretase presenilin and b-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-b. Caspase-12 is ubiquitously expressed in mouse tissues.
- Shipping Conditions:
- Blue Ice