GTX10427
RIP antibody
Cannot supply to this region.
- SKU:
- GTX10427
- Additional Names:
- receptor interacting serine/threonine kinase 1 , IMD57 , RIP , RIP-1 , RIP1
- Application:
- WB
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 1% BSA, 15mM Sodium azide.
- Immunogen:
- synthetic peptide corresponding to the C-terminal region of human RIP (amino acids 634-650), conjugated to KLH.
- Uniprot:
- Q13546
- Synonyms:
- AIEFL;cell death protein RIP;IMD57;receptor (TNFRSF)-interacting serine-threonine kinase 1;receptor-interacting protein 1;receptor-interacting protein kinase 1;receptor-interacting serine/threonine-protein kinase 1;RIP;RIP-1;RIP1;serine/threonine-protein kinase RIP
- Extra Details:
- RIP (Receptor Interacting Protein) is a 74 kD Ser/Thr kinase which interacts with CD95 (Fas/APO1) receptor and the tumor necrosis factor receptor (TNFR1). It is a cell death domain adapter protein which can bind to the adapter proteins TRADD, RAID (CRADD) and TRAF2. RIP contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing an intracellular death domain motif. RIP activates both p38 MAP Kinase and SAPK families.3 In-vitro, RIP induces apoptosis, as well as SAPK/JNK and NF-kB activation. NF-kB activation through TRADD, TRAF2 and RIP can be triggered also by DR3/APO3 upon activation with APO3/Tweak ligand.DR4 and DR5 also use FADD, TRADD, and RIP in their signal transduction pathways. RIP-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age. RIP possesses kinase activity as it autophosphorylates itself on serine and threonine residues.
- Shipping Conditions:
- Blue Ice