MAP3K8 antibody [N3C3]

Cannot supply to this region.

SKU:: GTX102711
Additional Names:: mitogen-activated protein kinase kinase kinase 8 , AURA2 , COT , EST , ESTF , MEKK8 , TPL2 , Tpl-2 , c-COT
Application:: WB, IHC-P, IF, ICC
Concentration:: 0.33 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse
Buffer:: PBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human MAP3K8. The exact sequence is proprietary.
Clone:: N3C3
Uniprot:: P41279
Synonyms:: augmented in rheumatoid arthritis 2;AURA2;c-COT;Cancer Osaka thyroid oncogene;COT;cot (cancer Osaka thyroid) oncogene;EST;ESTF;Ewing sarcoma transformant;MEKK8;mitogen-activated protein kinase kinase kinase 8;proto-oncogene c-Cot;proto-oncogene serine/threoine protein kinase;Serine/threonine-protein kinase cot;Tpl-2;TPL2;tumor progression locus 2
Extra Details:: This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. [provided by RefSeq]

Shipping Conditions:: Blue Ice