beta-TrCP antibody [N1C1]

Cannot supply to this region.

SKU:: GTX102667
Additional Names:: beta-transducin repeat containing E3 ubiquitin protein ligase , BETA-TRCP , FBW1A , FBXW1 , FBXW1A , FWD1 , bTrCP , bTrCP1 , betaTrCP
Application:: WB, IHC-P
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Rat
Buffer:: 0.1M Tris, 0.1M Glycine, 10% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human beta-TrCP. The exact sequence is proprietary.
Clone:: N1C1
Uniprot:: Q9Y297
Synonyms:: BETA-TRCP;beta-TrCP1;betaTrCP;bTrCP;bTrCP1;E3RSIkappaB;epididymis tissue protein Li 2a;F-box and WD repeats protein beta-TrCP;F-box and WD-repeat protein 1B;F-box/WD repeat-containing protein 1A;FBW1A;FBXW1;FBXW1A;FWD1;pIkappaBalpha-E3 receptor subunit
Extra Details:: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway. [provided by RefSeq]

Shipping Conditions:: Blue Ice