CD71 antibody [N2C1], Internal

Cannot supply to this region.

SKU:: GTX102596
Additional Names:: transferrin receptor , CD71 , IMD46 , T9 , TFR , TFR1 , TR , TRFR , p90
Application:: WB, IF, ICC
Concentration:: 0.47 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse
Buffer:: PBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300.
Immunogen:: Recombinant protein encompassing a sequence within the Extracellular domain of human CD71. The exact sequence is proprietary.
Clone:: N2C1
Uniprot:: P02786
Synonyms:: CD71;IMD46;p90;T9;TFR;TFR1;TR;transferrin receptor protein 1;TRFR
Extra Details:: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.