MDM2 antibody

Cannot supply to this region.

SKU:: GTX100654
Additional Names:: MDM2 proto-oncogene , ACTFS , HDMX , hdm2
Application:: IF, ICC
Concentration:: 0.62 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: 0.1M Tris, 0.1M Glycine, 10% Glycerol, 0.01% Thimerosal.
Immunogen:: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human MDM2. The exact sequence is proprietary.
Uniprot:: Q00987
Synonyms:: ACTFS;Double minute 2 protein;double minute 2, human homolog of; p53-binding protein;E3 ubiquitin-protein ligase Mdm2;hdm2;HDMX;LSKB;MDM2 oncogene, E3 ubiquitin protein ligase;MDM2 proto-oncogene, E3 ubiquitin protein ligase;Mdm2, p53 E3 ubiquitin protein ligase homolog;Mdm2, transformed 3T3 cell double minute 2, p53 binding protein;oncoprotein Mdm2;p53-binding protein Mdm2;RING-type E3 ubiquitin transferase Mdm2
Extra Details:: This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq]

Shipping Conditions:: Blue Ice