GTX100604
JIP1 antibody
Cannot supply to this region.
- SKU:
- GTX100604
- Additional Names:
- mitogen-activated protein kinase 8 interacting protein 1 , IB1 , JIP-1 , JIP1 , PRKM8IP
- Application:
- WB, IHC-P
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 0.1M Tris, 0.1M Glycine, 10% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human JIP1. The exact sequence is proprietary.
- Uniprot:
- Q9UQF2
- Synonyms:
- C-Jun-amino-terminal kinase-interacting protein 1;IB-1;IB1;islet-brain 1;JIP-1;JIP1;JNK MAP kinase scaffold protein 1;JNK-interacting protein 1;Mitogen-activated protein kinase 8-interacting protein 1;PRKM8 interacting protein;PRKM8IP
- Extra Details:
- The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq]
- Shipping Conditions:
- Blue Ice