Drosha antibody [GT1178]

Cannot supply to this region.

SKU:: GTX09511
Additional Names:: drosha ribonuclease III , ETOHI2 , HSA242976 , RANSE3L , RN3 , RNASE3L , RNASEN
Application:: WB, IF, ICC
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: A synthesized peptide derived from hmuan Drosha
Clone:: GT1178
Uniprot:: Q9NRR4
Synonyms:: drosha, double-stranded RNA-specific endoribonuclease;ETOHI2;HSA242976;nuclear RNase III Drosha;p241;Protein Drosha;putative protein p241 which interacts with transcription factor Sp1;putative ribonuclease III;RANSE3L;ribonuclease 3;Ribonuclease III;ribonuclease type III, nuclear;RN3;RNase III;RNASE3L;RNASEN
Extra Details:: This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a hmuan cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in hmuan patients with kidney cancer. [provided by RefSeq, Sep 2016]

Shipping Conditions:: Blue Ice