LRP2 antibody [ARC63830]

Cannot supply to this region.

SKU:: GTX04758
Additional Names:: DBS,GP330,LDL receptor related protein 2,LRP2,Lrp2,Megalin
Application:: Flow Cytometry, WB, IHC-P
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, 0.05% BSA, 50% glycerol, 0.05% proclin300.
Immunogen:: Recombinant fusion protein containing a sequence corresponding to amino acids 4446-4655 of human intracellular Megalin/LRP2 (NP_004516.2).
Clone:: ARC63830
Uniprot:: P98164
Synonyms:: calcium sensor protein;DBS;glycoprotein 330;GP330;Heymann nephritis antigen homolog;low-density lipoprotein receptor-related protein 2;LRP-2;megalin
Extra Details:: The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]

Shipping Conditions:: Blue Ice