ALK antibody [20A85]

Cannot supply to this region.

SKU:: GTX04501
Additional Names:: ALK receptor tyrosine kinase , CD246 , NBLST3
Application:: IHC-P, IF, ICC
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, 150mM NaCl, 0.04-0.05% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: A synthesized peptide, aa410-536, derived from human ALK
Clone:: 20A85
Uniprot:: Q9UM73
Synonyms:: ALK tyrosine kinase receptor;Anaplastic lymphoma kinase;anaplastic lymphoma receptor tyrosine kinase;CD246;CD246 antigen;mutant anaplastic lymphoma kinase;NBLST3
Extra Details:: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

Shipping Conditions:: Blue Ice