GTX03417
AXIN1 antibody
Cannot supply to this region.
- SKU:
- GTX03417
- Additional Names:
- axin 1 , AXIN , PPP1R49
- Application:
- WB
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% Glycerol, 0.02% sodium azide.
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human AXIN1 (NP_851393.1).
- Uniprot:
- O15169
- Synonyms:
- AXIN;axin-1;axis inhibition protein 1;axis inhibitor 1;fused, mouse, homolog of;PPP1R49;protein phosphatase 1, regulatory subunit 49
- Extra Details:
- This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
- Shipping Conditions:
- Blue Ice