GTX02580
PLCE1 antibody
Cannot supply to this region.
- SKU:
- GTX02580
- Additional Names:
- phospholipase C epsilon 1 , NPHS3 , PLCE , PPLC
- Application:
- WB, IHC-P, IF, ICC
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- A synthesized peptide derived from human PLCE1, corresponding to a region within C-terminal amino acids.
- Uniprot:
- Q9P212
- Synonyms:
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1;NPHS3;pancreas-enriched phospholipase C;phosphoinositide phospholipase C;phosphoinositide phospholipase C-epsilon-1;phosphoinositide-specific phospholipase C epsilon-1;Phospholipase C-epsilon-1;PLC-epsilon-1;PLCE;PPLC
- Extra Details:
- This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
- Shipping Conditions:
- Blue Ice